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WormBase is an online biological database about the biology and genome of the nematode model organism Caenorhabditis elegans and contains information about other related nematodes. [1] [2] WormBase is used by the C. elegans research community both as an information resource and as a place to publish and distribute their results. The database is ...
Capitalizing on the World Wide Web, WormBook links in-text references (e.g. genes, alleles, proteins, literature citations) with primary biological databases such as WormBase and PubMed. C. elegans was the first multicellular organism to have its genome sequenced [6] and is a model organism for studying developmental genetics and neurobiology.
C. elegans is notable in animal sleep studies as the most primitive organism to display sleep-like states. In C. elegans, a lethargus phase occurs shortly before each moult. [122] C. elegans has also been demonstrated to sleep after exposure to physical stress, including heat shock, UV radiation, and bacterial toxins. [123]
C. elegans has been used in studies of development and neurobiology. WormBase has information from nine species and five are from the genus Caenorhabditis, one of which is C. elegans. WormBase provides: a genome browser, genome, gene and protein sets for searches on sequence similarities and gene and protein summaries. [3]
Much of the functionality of AceDB for C. elegans has been made available through the WormBase database. [3] Features included: a graphical user interface with many specific displays and tools for genomic data; open-source software; package that implements a simple web browser interface allowing the database to accessed from anywhere
C. nigoni is the closest relative of C. briggsae, and the two species can occasionally produce somewhat fertile hybrids. [12] Caenorhabditis remanei - genome sequenced by WashU GSC. [13] More closely related to C. briggsae than C. elegans, C. remanei is a gonochoristic (male-female obligate) species in the Elegans group.
RDE-1 (RNAi-DEfective 1) is a primary Argonaute protein required for RNA-mediated interference (RNAi) in Caenorhabditis elegans.The rde-1 gene locus was first characterized in C. elegans mutants resistant to RNAi, and is a member of a highly conserved Piwi gene family that includes plant, Drosophila, and vertebrate homologs.
In a study C. elegans were starved and in stressful conditions such as a high salt environment. As a result there was a connection drawn between the pathway leading to the dauer stage and the pathway leading to bagging. Bagging was seen to be induced under stress, and was reversible if worms were relieved of the stress before internal larvae ...