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Owing to the ubiquity of the trade name Novocain or Novocaine, in some regions, procaine is referred to generically as novocaine. It acts mainly as a sodium channel blocker. [2] Today, it is used therapeutically in some countries due to its sympatholytic, anti-inflammatory, perfusion-enhancing, and mood-enhancing effects. [3]
Sodium channel blockers are also used as local anesthetics and anticonvulsants. [5] Sodium channel blockers have been proposed for use in the treatment of cystic fibrosis, [6] but current evidence is mixed. [7] It has been suggested that the analgesic effects of some antidepressants may be mediated in part via sodium channel blockade. [8]
Procainamide (PCA) is a medication of the antiarrhythmic class used for the treatment of cardiac arrhythmias.It is a sodium channel blocker of cardiomyocytes; thus it is classified by the Vaughan Williams classification system as class Ia.
Pages in category "Sodium channel blockers" The following 77 pages are in this category, out of 77 total. ... Procaine; Promethazine; Propafenone; Propranolol; Q ...
Introducing specific sodium channel blockers into a tissue allows for the preferential binding of the blocker to sodium channels, which results in an ultimate inhibition of the flow of sodium into the tissue. Over time, this mechanism leads to an overall decrease in tissue excitation.
procaine: Novocain, borocaine (procaine borate), ethocaine 1904 (Alfred Einhorn) 1905 (Heinrich Braun) procainamide: proparacaine: proxymetacaine propoxycaine [16] Pyrrocaine [17] quinisocaine dimethisoquin [18] ropivacaine: Naropin 1957 (Ekenstam) 1997 trimecaine: Mesdicain, Mesocain, Mesokain tetracaine: amethocaine, Dicaine, Pontocaine
Benzonatate is a local anesthetic and voltage-gated sodium channel blocker. [6] [unreliable medical source?] It is theorized to work by inhibiting stretch receptors in the lungs, in turn suppressing the cough reflex in the brain. [6] [unreliable medical source?] [7] Benzonatate is structurally related to other local anesthetics like procaine ...
20264 Ensembl ENSG00000185313 ENSMUSG00000034533 UniProt Q9Y5Y9 Q6QIY3 RefSeq (mRNA) NM_001293306 NM_001293307 NM_006514 NM_001205321 NM_009134 RefSeq (protein) NP_001280235 NP_001280236 NP_006505 NP_001192250 NP_033160 Location (UCSC) Chr 3: 38.7 – 38.82 Mb Chr 9: 119.44 – 119.55 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Na v 1.8 is a sodium ion channel subtype that in ...