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  2. SOD1 - Wikipedia

    en.wikipedia.org/wiki/SOD1

    SOD1 binds copper and zinc ions and is one of three superoxide dismutases responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic and mitochondrial intermembrane space protein, acting as a homodimer to convert naturally occurring, but harmful, superoxide radicals to molecular oxygen and hydrogen peroxide.

  3. Superoxide dismutase - Wikipedia

    en.wikipedia.org/wiki/Superoxide_dismutase

    Mutations in SOD1 can cause familial ALS (several pieces of evidence also show that wild-type SOD1, under conditions of cellular stress, is implicated in a significant fraction of sporadic ALS cases, which represent 90% of ALS patients.), [45] by a mechanism that is presently not understood, but not due to loss of enzymatic activity or a ...

  4. Tofersen - Wikipedia

    en.wikipedia.org/wiki/Tofersen

    Tofersen, sold under the brand name Qalsody, is a medication used for the treatment of amyotrophic lateral sclerosis (ALS). [2] Tofersen is an antisense oligonucleotide that targets the production of superoxide dismutase 1, an enzyme whose mutant form is commonly associated with amyotrophic lateral sclerosis.

  5. Canine degenerative myelopathy - Wikipedia

    en.wikipedia.org/wiki/Canine_degenerative_myelopathy

    Mutations in SOD1 are also associated with familial amyotrophic lateral sclerosis (Lou Gehrig's disease) in people. [5] More than 100 SOD1 gene mutations are involved in human familial amyotrophic lateral sclerosis (ALS), and the pathologic spinal lesions of ALS are similar to those of canine DM, making canine DM a potentially useful animal ...

  6. Genetics of amyotrophic lateral sclerosis - Wikipedia

    en.wikipedia.org/wiki/Genetics_of_amyotrophic...

    SOD1: 21q22.1 autosomal dominant, autosomal recessive: 1993 The first gene associated with ALS, SOD1 accounts for about 12% of fALS and 1-2% of sALS. [2] Susceptibility to ALS1 has also been linked to mutations in the following genes: DCTN1, [14] PRPH, [15] and NEFH. [16] ALS2: 205100: ALS2: 2q33.1 autosomal recessive 2001 Juvenile-onset ALS3 ...

  7. Biogen (BIIB) Q4 2024 Earnings Call Transcript - AOL

    www.aol.com/finance/biogen-biib-q4-2024-earnings...

    In Friedreich's ataxia and Qalsody in SOD1 ALS. Leveraging the results of the Skyclarys-positive MOXIe trial, we obtained approval in Chile and currently have 13 additional regulatory filings ...

  8. CCS (gene) - Wikipedia

    en.wikipedia.org/wiki/CCS_(gene)

    The structure of domain II greatly resembles that of SOD1 which allows it to perform the function of binding to SOD1. [5] Domain III contains a CXC Cu binding motif and performs the Cu insertion and subsequent disulfide oxidation of SOD1. [5] When CCS docks to SOD1, cysteine 244 of CCS and 57 of SOD1 form a disulfide linkage. [6]

  9. NYT ‘Connections’ Hints and Answers Today, Wednesday, February 19

    www.aol.com/nyt-connections-hints-answers-today...

    1. Things you might see at the beach (near the water). 2. Minor damage. 3. These noises are usually associated with a particular device. 4. The words in this category precede a common four-letter ...