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  2. Amyloid beta - Wikipedia

    en.wikipedia.org/wiki/Amyloid_beta

    Amyloid beta (Aβ, Abeta or beta-amyloid) denotes peptides of 36–43 amino acids that are the main component of the amyloid plaques found in the brains of people with Alzheimer's disease. [2] The peptides derive from the amyloid-beta precursor protein (APP), which is cleaved by beta secretase and gamma secretase to yield Aβ in a cholesterol ...

  3. Amyloid - Wikipedia

    en.wikipedia.org/wiki/Amyloid

    Native-like amyloid fibrils in which native β-sheet containing proteins maintain their native-like structure in the fibrils have also been proposed. [50] There are few developed ideas on how the complex backbone topologies of disulfide-constrained proteins, which are prone to form amyloid fibrils (such as insulin and lysozyme), adopt the ...

  4. Amyloid plaques - Wikipedia

    en.wikipedia.org/wiki/Amyloid_plaques

    Amyloid beta (Aβ) is a small protein, most often 40 or 42 amino acids in length, that is released from a longer parent protein called the Aβ-precursor protein (APP). [24] APP is produced by many types of cell in the body, but it is especially abundant in neurons. It is a single-pass transmembrane protein, passing once through cellular ...

  5. New test may detect Alzheimer's years before tau clumps ... - AOL

    www.aol.com/lifestyle/test-may-detect-alzheimers...

    Amyloid-beta: As Alzheimer’s disease develops, amyloid precursor proteins clump together to create amyloid-beta plaques, which eventually disrupt how brain cells work. Tau: In the healthy brain ...

  6. New study challenges amyloid-beta theory on cause for ... - AOL

    www.aol.com/lifestyle/study-challenges-amyloid...

    New research suggests that the lessening of amyloid-beta in the brain is behind cognitive decline in Alzheimer's and boosting brain protein amounts may offer cognitive benefits.

  7. Beta sheet - Wikipedia

    en.wikipedia.org/wiki/Beta_sheet

    Beta sheets consist of beta strands (β-strands) connected laterally by at least two or three backbone hydrogen bonds, forming a generally twisted, pleated sheet. A β-strand is a stretch of polypeptide chain typically 3 to 10 amino acids long with backbone in an extended conformation .

  8. Biochemistry of Alzheimer's disease - Wikipedia

    en.wikipedia.org/wiki/Biochemistry_of_Alzheimer's...

    Amyloid beta monomers are soluble and contain short regions of beta sheet and polyproline II helix secondary structures in solution, [5] though they are largely alpha helical in membranes; [6] however, at sufficiently high concentration, they undergo a dramatic conformational change to form a beta sheet-rich tertiary structure that aggregates ...

  9. Alpha sheet - Wikipedia

    en.wikipedia.org/wiki/Alpha_sheet

    The alpha sheet has been proposed as a possible intermediate state in the conformational change in the formation of amyloid fibrils by peptides and proteins such as amyloid beta, poly-glutamine repeats, lysozyme, prion proteins, and transthyretin repeats, all of which are associated with protein misfolding disease.

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