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Itraconazole is a relatively well-tolerated drug (although not as well tolerated as fluconazole or voriconazole) and the range of adverse effects it produces is similar to the other azole antifungals: [22] elevated alanine aminotransferase levels are found in 4% of people taking itraconazole
Some azole drugs may disrupt estrogen production in pregnancy, affecting pregnancy outcome. [26] Oral fluconazole is not associated with a significantly increased risk of birth defects overall, although it does increase the odds ratio of tetralogy of Fallot, but the absolute risk is still low. [27] Women using fluconazole during pregnancy have ...
Some people are allergic to azole(s). Some azole drugs have adverse side-effects. Some azole drugs may disrupt estrogen production in pregnancy, affecting pregnancy outcome. [4] [verification needed] Carbimazole should be used judiciously in pregnancy as it crosses the placenta.
In pregnancy, use on the skin or in the vagina is believed to be safe. [2] There is no evidence of harm when used by mouth during pregnancy but this has been less well studied. [2] When used by mouth, greater care should be taken in those with liver problems. [2] It is in the azole class of medications and works by disrupting the fungal cell ...
Topical nicotinamide and topical zinc are safe, however, there are no FDA pregnancy category ratings. [27] [28] Topical salicylic acid and topical dapsone are classified as FDA pregnancy category C. [23] [28] Acne medications to avoid during pregnancy include oral isotretinoin and topical tazarotene as there have been reports of birth defects.
Data analyzed by CNN shows mifepristone — the first drug in the medication abortion process — is even safer than some common, low-risk prescription drugs, including penicillin and Viagra.
One, and only one, lone pair of electrons from each heteroatom in the ring is part of the aromatic bonding in an azole. Names of azoles maintain the prefix upon reduction (e.g., pyrazoline, pyrazolidine). The numbering of ring atoms in azoles starts with the heteroatom that is not part of a double bond, and then proceeds towards the other ...
A 2023 systematic review looked at 23 records of pregnant animals who were given glucagon-like peptide 1 (GLP-1) agonists — the class of drug Ozempic belongs to — or sodium-glucose co ...