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A phase I clinical trial in cancer patients was performed in 2006. [11] A phase III trial treating thyroid cancer patients started in March 2011. [12] Lenvatinib was granted orphan drug status for treatment of various types of thyroid cancer that do not respond to radioiodine in the US and Japan in 2012 and in Europe in 2013. [13]
Results of a phase III clinical trial in triple-negative breast cancer were reported in October 2019. [89] Results of a phase II clinical trial in Merkel-cell carcinoma were reported in June 2016. [90] Results of a clinical trial in people with untreatable metastases arising from various solid tumors were reported in 2017. [91]
mRNA-4157/V940 is an mRNA based cancer vaccine encapsulated in solid lipid nanoparticles.The 34 mRNA sequences in mRNA-4157/V940 vaccine were generated by an automated algorithm integrated with workflow based on massive parallel sequencing of tissue generated from cancer patients. [1]
The Breast Cancer Research Foundation (BCRF) is an independent, not-for-profit organization which has raised $569.4 million to support clinical and translational research on breast cancer at medical institutions in the United States and abroad. [1] BCRF currently funds over 255 researchers in 14 countries. [2]
Active clinical use (clinical trial) Dawon Medax [72] 9 Be(p,n) 9 B LINAC BNCT Clinic in the BRC Center, Songdo, Incheon, South Korea 2022 Active clinical use (clinical trial) University of Tsukuba iBNCT [73] 9 Be(p,n) 9 B LINAC University of Tsukuba, Tokai, Ibaraki, Japan 2024 Active clinical use (clinical trial) Neutron Therapeutics [74 ...
Immunotherapy: mechanism of action for Durvalumab, Pembrolizumab, Ipilimumab, Atezolizumab. [20]A phase Ib clinical trial of durvalumab and tremelimumab showed some activity in non-small cell lung cancer (NSCLC) [21] Phase I data in advanced metastatic urothelial bladder (Study 1108) has led to FDA breakthrough therapy designation.
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Encorafenib is indicated in combination with binimetinib, for the treatment of people with unresectable or metastatic melanoma with a BRAF V600E or V600K mutation, as detected by an FDA-approved test; [2] in combination with cetuximab, for the treatment of adults with metastatic colorectal cancer with a BRAF V600E mutation, as detected by an FDA-approved test, after prior therapy; [2] in ...
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