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Telomerase are found specifically to target shorter telomere over longer telomere, due to various regulatory mechanisms inside the cells that reduce the affinity of telomerase to longer telomeres. This preferential affinity maintains a balance within the cell such that the telomeres are of sufficient length for their function and yet, at the ...
The role of telomeres and telomerase in cell aging and cancer was established by scientists at biotechnology company Geron with the cloning of the RNA and catalytic components of human telomerase [9] and the development of a polymerase chain reaction (PCR) based assay for telomerase activity called the TRAP assay, which surveys telomerase ...
Since evidence has also shown that TERRA expression is regulated in a telomere-length-dependent manner, [3] it is believed that TERRA may play an important role along with telomerase to modulate the length of telomere repeats on chromosome ends. Generally speaking, cells with long telomeres exhibit greater TERRA expression while short telomeres ...
Telomerase RNA component, also known as TR, TER or TERC, is an ncRNA found in eukaryotes that is a component of telomerase, the enzyme used to extend telomeres. [ 3 ] [ 4 ] TERC serves as a template for telomere replication ( reverse transcription ) by telomerase.
As cellular phones become more popular, there have been plans to release cell phone numbers into public 411 and reverse number directories via a separate Wireless telephone directory. However, these plans have come under opposition from internet based privacy advocate groups, and blogs, often citing privacy concerns.
Telomeres are shortened with every duplication of DNA, and must be lengthened again. He studies telomerase , the enzyme that copies the telomeric sequences and lengthens them. [ 8 ] The active site protein subunits of telomerase comprise a new class of reverse transcriptases , enzymes previously thought to be restricted to viruses and ...
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Shelterin (also called telosome) is a protein complex known to protect telomeres in many eukaryotes from DNA repair mechanisms, as well as to regulate telomerase activity. In mammals and other vertebrates, telomeric DNA consists of repeating double-stranded 5'-TTAGGG-3' (G-strand) sequences (2-15 kilobases in humans) along with the 3'-AATCCC-5' (C-strand) complement, ending with a 50-400 ...