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Possible senolytic agents are under preliminary research, including some which are in early-stage human trials. [6] [7] [clarification needed] The majority of candidate senolytic compounds are repurposed anti-cancer molecules, such as the chemotherapeutic drug dasatinib and the experimental small molecule navitoclax.
Senotherapeutics refers to therapeutic agents/strategies that specifically target cellular senescence. [1] Senotherapeutics include emerging senolytic/senoptotic small molecules that specifically induce cell death in senescent cells [2] and agents that inhibit the pro-inflammatory senescent secretome. [3]
The term "engineered negligible senescence" first appeared in print in Aubrey de Grey's 1999 book The Mitochondrial Free Radical Theory of Aging. [8] De Grey defined SENS as a "goal-directed rather than curiosity-driven" [9] approach to the science of aging, and "an effort to expand regenerative medicine into the territory of aging". [10]
A new study shows how drugs and supplements for aging could be tested in months, not years, if more research was done on ovaries. ... A radical new idea to speed up anti-aging research: Test ...
Scientists report that some apparently senescent cells – which are targeted by anti-aging senolytics – are required for regeneration, and suggest tailoring senolytics to precisely target harmful senescent cells while leaving the ones involved in regeneration intact. [211] [212]
The strict anti-aging routine of a 45-year-old CEO who spends millions a year to be 18 again—from diet to exercise. This story was originally featured on Fortune.com. Show comments.
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