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According to reviews, it is thought that senolytics can be administered intermittently while being as effective as continuous administration. This could be an advantage of senolytic drugs and decrease adverse effects, for instance circumventing potential off-target effects. [6] [12] [13] [14]
Senotherapeutics refers to therapeutic agents/strategies that specifically target cellular senescence. [1] Senotherapeutics include emerging senolytic/senoptotic small molecules that specifically induce cell death in senescent cells [2] and agents that inhibit the pro-inflammatory senescent secretome. [3]
A geroprotector aims to affect the root cause of aging and age-related diseases, and thus prolong the life span of animals. [1] [2] Some possible geroprotectors include melatonin, [3] carnosine, [4] metformin, [5] rapamycin, [6] nicotinamide mononucleotide (NMN) [7] and delta sleep-inducing peptide.
Natural killer cells can use NKG2D killer activation receptors to detect the MICA and ULBP2 ligands which become upregulated on senescent cells. [16] [67] The senescent cells are killed using perforin pore-forming cytolytic protein. [66] CD8+ cytotoxic T-lymphocytes also use NKG2D receptors to detect senescent cells, and promote killing similar ...
Strategies for engineered negligible senescence (SENS) is a range of proposed regenerative medical therapies, either planned or currently in development, for the periodic repair of all age-related damage to human tissue.
Senescence-associated secretory phenotype (SASP) is a phenotype associated with senescent cells wherein those cells secrete high levels of inflammatory cytokines, immune modulators, growth factors, and proteases.
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