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A431 cells were established from an epidermoid carcinoma in the skin of an 85- year-old female patient. Epidermal growth factor (EGF) stimulation of A431 cells induces rapid tyrosine phosphorylation of intracellular signaling proteins which control cellular processes such as growth, proliferation and apoptosis.
These somatic mutations involving EGFR lead to its constant activation, which produces uncontrolled cell division. [20] In glioblastoma a specific mutation of EGFR, called EGFRvIII, is often observed. [21] Mutations, amplifications or misregulations of EGFR or family members are implicated in about 30% of all epithelial cancers. [22]
Gene splicing techniques are used to make chimeric proteins in which the Fv of an antibody, preferentially binding to a cancer cell, is attached to a potent bacterial toxin. Additionally, with his colleague Jesse Roth, he was the first to clearly demonstrate the presence of specific protein receptors on the surface of animal cells.
The two short-chain fatty acids in question are propionate and butyrate, which, the researchers who conducted the study found, altered gene expression both in healthy cells and in treated colon ...
Epithelial cell adhesion molecule (EpCAM), also known as CD326 among other names, is a transmembrane glycoprotein mediating Ca 2+-independent homotypic cell–cell adhesion in epithelia. [5] EpCAM is also involved in cell signaling, [ 6 ] migration, [ 7 ] proliferation, and differentiation. [ 8 ]
A431 may refer to: A431 road (England), a road between Bath and Bristol; A431 cells, an experimental cell line used in biomedical research
An immortalised cell line is a population of cells from a multicellular organism that would normally not proliferate indefinitely but, due to mutation, have evaded normal cellular senescence and instead can keep undergoing division. The cells can therefore be grown for prolonged periods in vitro. The mutations required for immortality can occur ...
BLT2 is a cell surface receptor that functions by recognizing, binding, and mediating responses to a particular set of messenger molecules or ligands.These messenger ligands are any one of a range of structurally different arachidonic acid metabolites made and released by nearby cells to act as paracrine signals for coordinating responses between cells or autocrine signals for modulating their ...