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Levofloxacin and other fluoroquinolones have also been widely used for the treatment of uncomplicated community-acquired respiratory and urinary tract infections, indications for which major medical societies generally recommend the use of older, narrower spectrum drugs to avoid fluoroquinolone resistance development.
A chiral switch is a chiral drug that has already approved as racemate but has been re-developed as a single enantiomer. [1] [2] The term chiral switching was introduced by Agranat and Caner in 1999 [3] to describe the development of single enantiomers from racemate drugs. For example, levofloxacin is a chiral switch of racemic ofloxacin.
Later in late 1970s studies indicated that the (R)- enantiomer is an effective sedative, the (S)-enantiomer harbors teratogenic effect and causes fetal abnormalities. [ 53 ] [ 54 ] [ 55 ] Later studies established that under biological conditions the ( R) -thalidomide, good partner, undergoes an in vivo metabolic inversion to the ( S ...
However, the enantiomers are converted into each other in vivo. [18] As a result, dosing with a single-enantiomer form of the drug will still lead to both the enantiomers eventually being present in the patient's serum and thus would not prevent adverse effects—at best, it might reduce them if the rate of in vivo conversion can be slowed. [19]
In one study, [46] [47] 1534 juvenile patients (age 6 months to 16 years) treated with levofloxacin as part of three efficacy trials were followed up to assess all musculoskeletal events occurring up to 12 months after treatment. At 12 months' follow-up, the cumulative incidence of musculoskeletal adverse events was 3.4%, compared to 1.8% among ...
HIV prevention, treatment, deaths as thousands lose jobs. ... Children are sold as fighters." Women and children walk through al-Hol camp in Syria, on Jan. 8, 2020. Hearts and minds.
Case highlights tragic impact of trauma on children. One of the suspects − described as a 16-year-old − was reported missing on Jan. 12 and has "a history of disorderly conduct, malicious ...
The selection and use of essential medicines: report of the WHO Expert Committee, 2017 (including the 20th WHO Model List of Essential Medicines and the 6th Model List of Essential Medicines for Children). Geneva: World Health Organization. hdl: 10665/259481. ISBN 978-92-4-121015-7. ISSN 0512-3054. WHO technical report series; no. 1006.