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Hyperthermic intraperitoneal chemotherapy (HIPEC) is a type of hyperthermia therapy used in combination with surgery in the treatment of advanced abdominal cancers. [1] In this procedure, warmed anti-cancer medications are infused and circulated in the peritoneal cavity (abdomen) for a short period of time.
Ovarian cancer is highly treatable with surgery for almost all cases with well-differentiated stage-1 tumour. [4] [33] Higher tumour grades may benefit from adjuvant treatment such as platinum-based chemotherapy. [4] [33] Optimal debulking is used to treat cases where cancer has spread to become macroscopically advanced.
Debulking is the reduction of as much of the bulk of a tumour without the intention of a complete eradication. It is usually achieved by surgical removal. [1] [2] When performed for curative intent, it is a different procedure, which is called surgical debulking of tumors is known as cytoreduction or cytoreductive surgery [3] (CRS); "cytoreduction" refers to reducing the number of tumor cells.
Ovarian cancer is staged using the FIGO staging system and uses information obtained after surgery, which can include a total abdominal hysterectomy via midline laparotomy, removal of (usually) both ovaries and Fallopian tubes, (usually) the omentum, pelvic (peritoneal) washings, assessment of retroperitoneal lymph nodes (including the pelvic ...
Cytoreductive surgery (CRS) is a surgical procedure that aims to reduce the amount of cancer cells in the abdominal cavity for patients with tumors that have spread intraabdominally (peritoneal carcinomatosis). It is often used to treat ovarian cancer but can also be used for other abdominal malignancies.
An alternative approach involves interval debulking surgery, which combines neoadjuvant chemotherapy with post-debulking chemotherapy. While laparoscopic surgery is suitable for early-stage cancer, advanced cases require more extensive procedures like lymphadenectomy. Secondary surgery may be an option for recurrent cases, effectiveness ...
The most common types of cancer discovered through abdominal surgery are gastrointestinal, such as colon or stomach, or genital or urinary, Dr. Ben Ho Park, director of precision oncology at ...
The typical advanced presentation as well as extra-ovarian spread seen in HGSC can require aggressive debulking procedures. [51] In some cases total abdominal hysterectomy will be performed, in other cases where the patient intends to bear children a salpingo-oophorectomy is performed instead.