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In military strategy, a choke point (or chokepoint), or sometimes bottleneck, is a geographical feature on land such as a valley, defile or bridge, or maritime passage through a critical waterway such as a strait, which an armed force is forced to pass through in order to reach its objective, sometimes on a substantially narrowed front and ...
Border checkpoint, a place on the land border between two states where travellers and/or goods are inspected; Security checkpoint, erected and enforced within contiguous areas under military or paramilitary control; Random checkpoint, a police or military checkpoint that is moved to various locations
Steps of the cell cycle. The restriction point occurs between the G 1 and S phases of interphase. The G 2-M checkpoint occurs between the G 2 and M phases. The spindle checkpoint occurs during the M phase. Key cyclins associated with each phase are shown.
Compressor characteristic is a mathematical curve that shows the behaviour of a fluid going through a dynamic compressor.It shows changes in fluid pressure, temperature, entropy, flow rate etc.) with the compressor operating at different speeds.
Two checkpoint kinase subtypes have been identified, Chk1 and Chk2. Chk1 is a central component of genome surveillance pathways and is a key regulator of the cell cycle and cell survival. Chk1 is required for the initiation of DNA damage checkpoints and has recently been shown to play a role in the normal (unperturbed) cell cycle. [ 9 ]
This checkpoint is the target of Merck & Co.'s melanoma drug Keytruda, which gained FDA approval in September 2014. The checkpoint is also the target of EMD Serono (Merck KGaA)'s drug Bavencio, which gained FDA approval in 2017. An advantage of targeting PD-1 is that it can restore immune function in the tumor microenvironment. [44] [38]
The G 1 phase, gap 1 phase, or growth 1 phase, is the first of four phases of the cell cycle that takes place in eukaryotic cell division. In this part of interphase, the cell synthesizes mRNA and proteins in preparation for subsequent steps leading to mitosis. G 1 phase ends when the cell moves into the S phase of interphase.
Checkpoint near Abu Dis, the West Bank A search conducted by the British at the entrance to Tel Aviv in the 1940s. Civilian checkpoints or security checkpoints are distinguishable from border or frontier checkpoints in that they are erected and enforced within contiguous areas under military or paramilitary control.