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Ivermectin is an antiparasitic drug. [7] After its discovery in 1975, [8] its first uses were in veterinary medicine to prevent and treat heartworm and acariasis. [9] Approved for human use in 1987, [10] it is used to treat infestations including head lice, scabies, river blindness (onchocerciasis), strongyloidiasis, trichuriasis, ascariasis and lymphatic filariasis.
Ivermectin, formulated from Avermectin, has a wide variety of uses in human beings. According to a paper (Ivermectin: “Wonder Drug” from Japan: the human use perspective) written by the drugs co-creator Satoshi Ōmura and Andy Crump for The Japan Academy, Ivermectin has improved the lives of billions of people worldwide and not solely for ...
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The macrolide ring is the lactone (cyclic ester) at upper left. Clarithromycin Roxithromycin. Macrolides are a class of mostly natural products with a large macrocyclic lactone ring to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. The lactone rings are usually 14-, 15-, or 16-membered.
ATCvet code QP54 Endectocides is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System for veterinary medicinal products, a system of alphanumeric codes developed by the World Health Organization (WHO) for the classification of drugs and other medical products for veterinary use.
Merck went on to study the treatment of elephantiasis. The research of Satoshi Ōmura, William Campbell, and their co-workers created a new class of drugs for the treatment of parasites. [3] [13] In 1987, Merck decided to donate Ivermectin to developing countries. [14] Campbell was instrumental in that decision.
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Subsequent research failed to confirm the utility of ivermectin for COVID-19, [85] [86] and in 2021 it emerged that many of the studies demonstrating benefit were faulty, misleading, or fraudulent. [ 87 ] [ 88 ] Nevertheless, misinformation about ivermectin continued to be propagated on social media and the drug remained a cause célèbre for ...