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One of propofol's most common side effects is pain on injection, especially in smaller veins. This pain arises from activation of the pain receptor, TRPA1, [54] found on sensory nerves and can be mitigated by pretreatment with lidocaine. [55] Less pain is experienced when infused at a slower rate in a large vein (antecubital fossa).
Propofol infusion syndrome (PRIS) is a rare syndrome which affects patients undergoing long-term treatment with high doses of the anaesthetic and sedative drug propofol. It can lead to cardiac failure , rhabdomyolysis , metabolic acidosis , and kidney failure , and is often fatal.
Opioid is a commonly administered adjuvant agent as the analgesic component of TIVA. However, when used with propofol, it might exacerbate the adverse hypotensive effects. [48] Other potential adverse effects include respiratory depression, bradycardia, delirium and potential for acute tolerance. [50]
The most common side effects of Journavx, according to the company’s website, include itching, muscle spasms, rash, and increased levels of an enzyme called creatine phosphokinase in the blood ...
A study confirmed that side effects like pancreatitis and kidney damage are possible while taking GLP-1s like Ozempic. Here's what a doctor wants you to know.
Adverse effects, like therapeutic effects of drugs, are a function of dosage or drug levels at the target organs, so they may be avoided or decreased by means of careful and precise pharmacokinetics, the change of drug levels in the organism in function of time after administration. Adverse effects may also be caused by drug interaction. This ...
Beloved ESPN basketball commentator Dick Vitale will make his return to broadcasting on Jan. 25 for Duke vs. Wake Forest basketball, the network announced Friday.. Vitale, 85, has battled four ...
Psychotomimetic effects limit the acceptance of ketamine; however, lamotrigine [38] and nimodipine [39] decrease psychotomimetic effects and can also be counteracted by benzodiazepines or propofol administration. [40] Ketofol is a combination of ketamine and propofol.