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About 10 [13] to 15% [1] of individuals initially or subsequently present with metastases, [2] most commonly in the lung, less commonly in the regional lymph nodes draining the site of the primary dermal tumor, [13] or, rarely, in the liver, kidney, soft tissue sites outside of the primary dermal tumor's areas, [3] mediastinum, or brain.
Dermatofibrosarcoma protuberans (DFSP) [2] is a rare locally aggressive malignant cutaneous soft-tissue sarcoma. DFSP develops in the connective tissue cells in the middle layer of the skin (dermis). [3] Estimates of the overall occurrence of DFSP in the United States are 0.8 to 4.5 cases per million persons per year.
A dermatofibroma, or benign fibrous histiocytomas, is a benign nodule in the skin, typically on the legs, elbows or chest of an adult. [3] It is usually painless. [3] It usually ranges from 0.2cm to 2cm in size but larger examples have been reported. [3] It typically results from mild trauma such as an insect bite. [3]
They can grow in all organs, arising from mesenchyme tissue. The term "fibroblastic" or "fibromatous" is used to describe tumors of the fibrous connective tissue. When the term fibroma is used without modifier, it is usually considered benign, with the term fibrosarcoma reserved for malignant tumors.
The term fibromatosis refers to a group of soft tissue tumors [1] which have certain characteristics in common, including absence of cytologic and clinical malignant features, a histology consistent with proliferation of well-differentiated fibroblasts, an infiltrative growth pattern, and aggressive clinical behavior with frequent local recurrence.
However, a benign tumor is not benign in the usual sense; the name merely specifies that it is not "malignant", i.e. cancerous. While benign tumors usually do not pose a serious health risk, they can be harmful or fatal. [2] Many types of benign tumors have the potential to become cancerous through a process known as tumor progression. For this ...
2 References. Toggle the table of contents. ... Epithelioid cell histiocytoma is a rare skin condition that is considered to be a variant of a dermatofibroma. [1]
Gardner fibroma (GF) (also termed Gardner-associated fibroma [1]) is a benign fibroblastic tumor (i.e. a tumor containing fibroblasts, the most common cell type in connective tissue). GF tumors typically develop in the dermis (i.e. layer of skin underneath the epidermis ) and adjacent subcutaneous tissue lying just below the dermis. [ 2 ]