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Amyloid shows up as homogeneous pink material in lamina propria and around blood vessels. 20× magnification. Amyloids are aggregates of proteins characterised by a fibrillar morphology of typically 7–13 nm in diameter , a β-sheet secondary structure (known as cross-β) and ability to be stained by particular dyes, such as Congo red . [ 1 ]
From the age of 60 years (10%) to the age of 80 years (60%), the proportion of people with senile plaques increases linearly. Women are slightly more likely to have plaques than are men. [ 45 ] [ 44 ] Both plaques and Alzheimer's disease also are more common in aging persons with trisomy -21 ( Down syndrome ).
Amyloid light chains deposition in shoulder joint causes enlarged shoulders, also known as "shoulder pad sign". [18] Amyloid light chain depositions can also cause bilateral symmetric polyarthritis. [18] The deposition of amyloid proteins in the bone marrow without causing plasma cell dyscrasias is called amyloidoma. It is commonly found in ...
Both blood and urine can be tested for the light chains which form amyloid deposits, however the diagnosis requires a sample of an amyloid deposit. [6] [10] A fine needle aspiration (FNA) may be done of the abdominal fat pad (which commonly contains amyloid deposits) to aid in the diagnosis of AL amyloidosis. The abdominal fat pad is much more ...
Wild-type transthyretin amyloid (WTTA), also known as senile systemic amyloidosis (SSA), [1] is a disease that typically affects the heart and tendons of elderly people. It is caused by the accumulation of a wild-type (that is to say a normal ) protein called transthyretin .
Regarding ideal numbers, the famous M.D. says: "Your blood pressure is supposed to be under 140 over 90, optimally closer to 120 over 80."
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