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FibroTest has been evaluated in relation to liver biopsy (the current reference standard in liver disease assessment) in people with hepatitis C, hepatitis B, [1] alcoholic liver disease, [2] and non-alcoholic fatty liver disease. [3] They are most useful for cirrhosis and less useful for other stages of liver disease. [4]
This results in jaundice, weight loss, coagulopathy, ... Hepatitis usually develops over years-long exposure to alcohol, occurring in 10 to 20% of alcoholics. [36]
In acute viral hepatitis, the GGT levels can peak at 2nd and 3rd week of illness, and remained elevated at 6 weeks of illness. GGT is also elevated in 30% of the hepatitis C patients. GGT can increase by 10 times in alcoholism. GGT can increase by 2 to 3 times in 50% of the patients with non-alcoholic liver disease.
“Hepatitis C is a blood-borne virus,” says Dr. Dieterich. “It is transmitted through the blood, so IV drug use is a major driver of the virus, especially now due to the heroin epidemic.
Transmission of hepatitis B virus results from exposure to infectious blood or body fluids containing blood. HBV is 50 to 100 times more infectious than human immunodeficiency virus (HIV) . [ 32 ] HBV can be transmitted through several routes of infection.
A long labor is associated with a greater risk of transmission. [24] ... treatment for hepatitis C results in reactivation of hepatitis B about 25% of the time. [104]
"Long-term" is relative—for instance, flu and COVID-19 shots offer protection for the current season's variants, while hepatitis B vaccinations can last a lifetime.
The test results correspond to stages F0-F4 and grades A0-A3 of the METAVIR scoring system. [20] In 2007 FibroTest was validated by French Health Authorities as a first-line diagnosis of liver injury before biopsy. It was recommended to be a better predictor than biopsy staging for hepatitis C complications and death. [21]