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  2. Nanopore sequencing - Wikipedia

    en.wikipedia.org/wiki/Nanopore_sequencing

    Nanopore sequencing is a third generation [1] approach used in the sequencing of biopolymers — specifically, polynucleotides in the form of DNA or RNA. Nanopore sequencing allows a single molecule of DNA or RNA be sequenced without PCR amplification or chemical labeling.

  3. Nanopore - Wikipedia

    en.wikipedia.org/wiki/Nanopore

    Schematic of Nanopore Internal Machinery and corresponding current blockade during sequencing. A nanopore is a pore of nanometer size. It may, for example, be created by a pore-forming protein or as a hole in synthetic materials such as silicon or graphene.

  4. DNA sequencing - Wikipedia

    en.wikipedia.org/wiki/DNA_sequencing

    Nanopore sequencing is referred to as "third-generation" or "long-read" sequencing, along with SMRT sequencing. Early industrial research into this method was based on a technique called 'exonuclease sequencing', where the readout of electrical signals occurred as nucleotides passed by alpha(α)-hemolysin pores covalently bound with ...

  5. Single-cell sequencing - Wikipedia

    en.wikipedia.org/wiki/Single-cell_sequencing

    Nanopore-based sequencing also offers a route for direct methylation sequencing without fragmentation or modification to the original DNA. Nanopore sequencing has been used to sequence the methylomes of bacteria, which are dominated by 6mA and 4mC (as opposed to 5mC in eukaryotes), but this technique has not yet been scaled down to single cells ...

  6. N50, L50, and related statistics - Wikipedia

    en.wikipedia.org/wiki/N50,_L50,_and_related...

    Given a set of contigs, the N50 is defined as the sequence length of the shortest contig at 50% of the total assembly length. It can be thought of as the point of half of the mass of the distribution; the number of bases from all contigs longer than the N50 will be close to the number of bases from all contigs shorter than the N50 .

  7. DNA sequencer - Wikipedia

    en.wikipedia.org/wiki/DNA_sequencer

    Oxford Nanopore Technologies' MinION sequencer is based on evolving nanopore sequencing technology to nucleic acid analyses. [37] The device is four inches long and gets power from a USB port. MinION decodes DNA directly as the molecule is drawn at the rate of 450 bases/second through a nanopore suspended in a membrane. [38]

  8. We know why cats knead. But here's why humans love it so much.

    www.aol.com/know-why-cats-knead-heres-100401607.html

    Humans love it when cats knead because the cute motion makes it look like cats are hard at work on a bakery assembly line.

  9. Base calling - Wikipedia

    en.wikipedia.org/wiki/Base_calling

    Base calling is the process of assigning nucleobases to chromatogram peaks, light intensity signals, or electrical current changes resulting from nucleotides passing through a nanopore. One computer program for accomplishing this job is Phred , which is a widely used base calling software program by both academic and commercial DNA sequencing ...