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Ceruloplasmin (or caeruloplasmin) is a ferroxidase enzyme that in humans is encoded by the CP gene. [ 5 ] [ 6 ] [ 7 ] Ceruloplasmin is the major copper -carrying protein in the blood, and in addition plays a role in iron metabolism .
Ceruloplasmin. Levels of ceruloplasmin are abnormally low (<0.2 g/L) in 80–95% of cases. [5] It can be present at normal levels, though, in people with ongoing inflammation, as it is an acute phase protein. Low ceruloplasmin is also found in Menkes disease and aceruloplasminemia, which are related to, but much rarer than Wilson's disease.
Aceruloplasminemia has an autosomal recessive pattern of inheritance.. Aceruloplasminemia is caused by a mutation (a five-base pair insertion in exon 7 [3]) in the CP gene, which provides instructions for making a protein called ceruloplasmin, a protein involved in iron transport and processing.
11979 Ensembl ENSG00000123191 ENSMUSG00000006567 UniProt P35670 Q64446 RefSeq (mRNA) NM_000053 NM_001005918 NM_001243182 NM_001330578 NM_001330579 NM_007511 RefSeq (protein) NP_000044 NP_001005918 NP_001230111 NP_001317507 NP_001317508 NP_000044.2 NP_000044.2 NP_001005918.1 NP_001230111.1 NP_031537 NP_001390638 Location (UCSC) Chr 13: 51.93 – 52.01 Mb Chr 8: 22.48 – 22.55 Mb PubMed search ...
When someone has Alzheimer's disease, chemical changes cause tau to detach from those microtubules and stick to other tau molecules, per the NIA. This forms threads that create tangles inside ...
4. Stress. Stress can lead to overeating, eating high-calorie or high-fat foods, and sleep loss. When you’re stressed, the stress hormone cortisol reduces your brain’s sensitivity to leptin ...
Copper deficiency, or hypocupremia, is defined as insufficient copper to meet the body's needs, or as a serum copper level below the normal range. [1] Symptoms may include fatigue, decreased red blood cells, early greying of the hair, and neurological problems presenting as numbness, tingling, muscle weakness, and ataxia. [2]
Botulism can cause double or blurred vision, slurred speech, drooping eyelids and difficulty swallowing or breathing. As symptoms progress, the muscles become progressively weakened.