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In toxicology, the margin of exposure (or MOE) of a substance is the ratio of its no-observed-adverse-effect level to its theoretical, predicted, or estimated dose or concentration of human intake. [1] It is used in risk assessment to determine the dangerousness of substances that are both genotoxic and carcinogenic. [2]
The framework replaced both non-internal model approaches: the Current Exposure Method (CEM) and the Standardised Method (SM). It is intended to be a "risk-sensitive methodology", i.e. conscious of asset class and hedging , that differentiates between margined and non-margined trades and recognizes netting benefits ; considerations ...
The DNEL is to be published in the manufacturer's chemical safety report (CSR) and, for hazard communication, in an extended safety data sheet. Correspondent to REACH legislation, the registrant (manufacturer or importer) of a substance has to indicate the DNELs for the most probable way of exposition (oral, dermal, inhalative) and the expected ...
Exposure Quantification, aims to determine the amount of a contaminant (dose) that individuals and populations will receive, either as a contact level (e.g., concentration in ambient air) or as intake (e.g., daily dose ingested from drinking water). This is done by examining the results of the discipline of exposure assessment. As a different ...
The exposure factor is usually a subjective value that the person assessing risk must define. It is represented in the impact of the risk over the asset, or percentage of asset lost. As an example, if the asset value is reduced two thirds, the exposure factor value is 0.66. If the asset is completely lost, the exposure factor is 1.0.
In engineering, a factor of safety (FoS) or safety factor (SF) expresses how much stronger a system is than it needs to be for an intended load.Safety factors are often calculated using detailed analysis because comprehensive testing is impractical on many projects, such as bridges and buildings, but the structure's ability to carry a load must be determined to a reasonable accuracy.
Margin of safety may refer to: Margin of safety (financial) in a financial context; Margin of safety (medicine) for pharmaceutical drugs; Margin of safety (accounting ...
An occupational exposure limit is an upper limit on the acceptable concentration of a hazardous substance in workplace air for a particular material or class of materials. It is typically set by competent national authorities and enforced by legislation to protect occupational safety and health.