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In vertebrates, the circulatory system is a system of organs that includes the heart, blood vessels, and blood which is circulated throughout the body. [1] [2] It includes the cardiovascular system, or vascular system, that consists of the heart and blood vessels (from Greek kardia meaning heart, and Latin vascula meaning vessels).
For this reason, the blood flow velocity is the fastest in the middle of the vessel and slowest at the vessel wall. In most cases, the mean velocity is used. [18] There are many ways to measure blood flow velocity, like videocapillary microscoping with frame-to-frame analysis, or laser Doppler anemometry. [19]
The adaptive flow that the circle of Willis introduces can also lead to reduced cerebral perfusion. [ 8 ] [ 9 ] In subclavian steal syndrome , blood is "stolen" from the vertebral artery on the affected side to preserve blood flow to the upper limb .
Cerebral blood flow (CBF) is the blood supply to the brain in a given period of time. [8] In an adult, CBF is typically 750 millilitres per minute or 15.8 ± 5.7% of the cardiac output . [ 9 ] This equates to an average perfusion of 50 to 54 millilitres of blood per 100 grams of brain tissue per minute.
Vascular resistance occurs when the vessels away from the heart oppose the flow of blood. Resistance is an accumulation of three different factors: blood viscosity, blood vessel length and vessel radius. [30] Blood viscosity is the thickness of the blood and its resistance to flow as a result of the different components of the blood.
Turbulent flow is present in circumstances under which Re > 4000. The range of 2000 < Re < 4000 is known as the transition range. Most blood flow in humans is laminar, having a Re of 300 or less, it is possible for turbulence to occur at very high flow rates in the descending aorta, for example, in highly conditioned athletes.
Perfusion is measured as the rate at which blood is delivered to tissue, [2] or volume of blood per unit time (blood flow) per unit tissue mass. The SI unit is m 3 /(s·kg) [ citation needed ] , although for human organs perfusion is typically reported in ml/min/g. [ 3 ]
Typically, blood flow velocities in the common carotid artery are measured as peak systolic velocity (PSV) and end diastolic velocity (EDV). In a study of normative men aged 20-29 years, the average PSV was 115 cm/sec and EDV was 32 cm/sec. In men 80 years and older, the average PSV was 88 cm/sec and EDV was 17 cm/sec. [7]