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Keratolytic Winter erythema (also known as Oudtshoorn disease [1] or Oudtshoorn skin [2] [3]) is a rare autosomal dominant skin disease of unknown cause which causes redness and peeling of the skin on the palms and soles. [4] Onset, increased prominence and severity usually occurs during winter. [5] [6] It is a type of genodermatosis. [7]
Pinta (also known as azul, carate, empeines, lota, mal del pinto, and tina) is a human skin disease caused by infection with the spirochete Treponema carateum, which is morphologically and serologically indistinguishable from the bacterium that causes syphilis and bejel.
Medetomidine is a veterinary anesthetic drug with potent sedative effects and emerging illicit drug adulterant. [ 1 ] It is a racemic mixture of two stereoisomers , levomedetomidine and dexmedetomidine , the latter being the isomer with the pharmacologic effect as an alpha 2- adrenergic agonist .
Together with Stevens–Johnson syndrome (SJS) it forms a spectrum of disease, with TEN being more severe. [2] Early symptoms include fever and flu-like symptoms. [2] A few days later the skin begins to blister and peel forming painful raw areas. [2] Mucous membranes, such as the mouth, are also typically involved. [2]
The rise of medetomidine comes as overdose deaths have fallen slightly. More than 107,000 people died of a drug overdose last year, down from about 111,000 in 2022, according to a recent report.
EDP does not usually have symptoms beside the macules and patches of discolored skin; however, some itching in these areas may occur. Because EDP is an uncommon disease of the skin, it is important to consider other skin diseases that may resemble erythema dyschromicum perstans, such as infectious diseases (i.e. leprosy or pinta ), reaction to ...
Identification of the physical symptoms is important to distinguish this disease from Papillon-Lefevre Syndrome. [6] Because of this, Haim-Munk syndrome is often diagnosed at an early age. [9] In many cases diagnosis of Haim–Munk syndrome may be difficult in small children, as many symptoms can be confused with other skin abnormalities.
Medetomidine, a powerful animal tranquilizer, has emerged as one of the latest substances found mixed with other common street drugs. The drug has recently been cited as the likely culprit behind ...