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  2. Untranslated region - Wikipedia

    en.wikipedia.org/wiki/Untranslated_region

    Although they are called untranslated regions, and do not form the protein-coding region of the gene, uORFs located within the 5' UTR can be translated into peptides. [1] The 5' UTR is upstream from the coding sequence. Within the 5' UTR is a sequence that is recognized by the ribosome which allows the ribosome to bind and initiate translation.

  3. File:5' UTR Secondary Structure.pdf - Wikipedia

    en.wikipedia.org/wiki/File:5'_UTR_Secondary...

    You are free: to share – to copy, distribute and transmit the work; to remix – to adapt the work; Under the following conditions: attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses ...

  4. Five prime untranslated region - Wikipedia

    en.wikipedia.org/wiki/Five_prime_untranslated_region

    Despite its name, the 5′ UTR, or a portion of it is sometimes translated into a protein product. [1] This product may involve in regulation of transcription, and translation of the main coding sequence of the mRNA, such as the sex-lethal gene in Drosophila. [2] Regulatory elements within 5′ UTRs have also been linked to mRNA export. [3]

  5. Three prime untranslated region - Wikipedia

    en.wikipedia.org/wiki/Three_prime_untranslated...

    Scientists use a number of methods to study the complex structures and functions of the 3′ UTR. Even if a given 3′-UTR in an mRNA is shown to be present in a tissue, the effects of localization, functional half-life, translational efficiency, and trans-acting elements must be determined to understand the 3′-UTR's full functionality. [ 7 ]

  6. Atlas of UTR Regulatory Activity - Wikipedia

    en.wikipedia.org/wiki/Atlas_of_UTR_Regulatory...

    The Atlas of UTR Regulatory Activity (AURA), [1] a biological database, now in its second version, [2] is a manually curated and comprehensive catalog of human 5' and 3' untranslated sequences (UTR) and UTR regulatory annotations. It includes basic annotation, phylogenetic conservation, binding sites for RNA-binding proteins and miRNA, cis ...

  7. Open reading frame - Wikipedia

    en.wikipedia.org/wiki/Open_reading_frame

    The 5’-UTR of about 50% of mammal mRNAs are known to contain one or several sORFs, [11] also called upstream ORFs or uORFs. However, less than 10% of the vertebrate mRNAs surveyed in an older study contained AUG codons in front of the major ORF. Interestingly, uORFs were found in two thirds of proto-oncogenes and related proteins.

  8. Coding region - Wikipedia

    en.wikipedia.org/wiki/Coding_region

    The coding region of a gene, also known as the coding DNA sequence (CDS), is the portion of a gene's DNA or RNA that codes for a protein. [1] Studying the length, composition, regulation, splicing, structures, and functions of coding regions compared to non-coding regions over different species and time periods can provide a significant amount of important information regarding gene ...

  9. Coronavirus 5′ UTR - Wikipedia

    en.wikipedia.org/wiki/Coronavirus_5′_UTR

    The first 150 to 200 nucleotides within the 5′ UTR of Alphacoronaviruses are highly structured and shown to be conserved on the structural level. The 5′ UTRs are predicted to contain three conserved stem-loops: [3] SL1 is important for viral replication, most likely playing a role in the template-switch of viral subgenomic RNA (sgRNA ...

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