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Glucocorticoid drugs currently being used act nonselectively, so in the long run they may impair many healthy anabolic processes. To prevent this, much research has been focused recently on the elaboration of selectively acting glucocorticoid drugs. Side effects include: Immunodeficiency (see section below)
Corticosteroids act as agonists of the glucocorticoid receptor and/or the mineralocorticoid receptor. [citation needed] In addition to their corticosteroid activity, some corticosteroids may have some progestogenic activity and may produce sex-related side effects. [10] [11] [12] [13]
Serious side effects include iatrogenic Cushing's syndrome, hypertension, osteoporosis, diabetes, infection, and skin atrophy. [9] Chemically, methylprednisolone is a synthetic pregnane steroid hormone derived from hydrocortisone and prednisolone. It belongs to a class of synthetic glucocorticoids and more generally, corticosteroids. It acts as ...
Topical glucocorticoids are the topical forms of glucocorticoids. Topical glucocorticoids are used in the treatment of many skin conditions. They provide anti-inflammatory, antimitotic, and immune-system suppressing actions through various mechanisms. [1] Hydrocortisone cream is a type of topical glucocorticoid that is commonly found on the market.
Although it is a structural analogue of tacrolimus, it acts somewhat differently and has different side-effects. Contrary to ciclosporin and tacrolimus, drugs that affect the first phase of T lymphocyte activation, sirolimus affects the second phase, namely signal transduction and lymphocyte clonal proliferation.
Serious side effects include an increased risk of infection, loss of bone strength, and cataracts. [16] Long-term use of the pill form may cause adrenal insufficiency. [16] Stopping the pills suddenly following long-term use may therefore be dangerous. [16] The inhaled form is generally safe in pregnancy. [16] Budesonide chiefly acts as a ...
Micrograph of fatty liver, as may be seen due to long-term prednisone use. Trichrome stain.. Short-term side effects, as with all glucocorticoids, include high blood glucose levels (especially in patients with diabetes mellitus or on other medications that increase blood glucose, such as tacrolimus) and mineralocorticoid effects such as fluid retention. [24]
The side effects of triamcinolone are similar to other corticosteroids. In short-term treatment of up to ten days, it has very few adverse effects; however, sometimes gastrointestinal bleeding is seen, as well as acute infections (mainly viral) and impaired glucose tolerance. [4]