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The cysteine cathepsins have attracted significant research effort as drug targets. [1] [2] Cancer, Cathepsin D is a mitogen and "it attenuates the anti-tumor immune response of decaying chemokines to inhibit the function of dendritic cells". Cathepsins B and L are involved in matrix degradation and cell invasion. [3] Stroke [4] Traumatic brain ...
Cathepsin L1 is a protein that in humans is encoded by the CTSL1 gene. [ 3 ] [ 4 ] [ 5 ] The protein is a cysteine cathepsin , a lysosomal cysteine protease that plays a major role in intracellular protein catabolism .
Download as PDF; Printable version; In other projects Wikidata item; Appearance. move to sidebar hide. Cathepsin L may refer to: Cathepsin L1, a human ...
An L-series is a Dirichlet series, usually convergent on a half-plane, that may give rise to an L-function via analytic continuation. The Riemann zeta function is an example of an L -function, and some important conjectures involving L -functions are the Riemann hypothesis and its generalizations .
The alpha/beta hydrolase superfamily is a superfamily of hydrolytic enzymes of widely differing phylogenetic origin and catalytic function that share a common fold. [1] The core of each enzyme is an alpha/beta-sheet (rather than a barrel), containing 8 beta strands connected by 6 alpha helices.
Cell lines grown in synthetic media avoid animal serum, which may pose a sterility problem, more specifically, preventing the spread of transmissible spongiform encephalopathies. [9] [10] [11] Another benefit is the avoidance of egg-allergen. Lastly, cell-based vaccines may be more effective given that, with egg-based vaccines, there is a risk ...
A calpain (/ ˈ k æ l p eɪ n /; [1] EC 3.4.22.52, EC 3.4.22.53) is a protein belonging to the family of calcium-dependent, non-lysosomal cysteine proteases (proteolytic enzymes) expressed ubiquitously in mammals and many other organisms.
The National Veterinary Research Institute (NVRI) is a research institute in Nigeria that was established in 1924 and has the mandate to conduct research into how to ably identify, treat and control animal diseases as well as the development of vaccines for such training and the provision of support services to livestock and poultry farmers.