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The synergy between trimethoprim and sulfamethoxazole was first described in the late 1960s. [25] [26] [27] Trimethoprim and sulfamethoxazole have a greater effect when given together than when given separately, because they inhibit successive steps in the folate synthesis pathway. They are given in a one-to-five ratio in their tablet ...
Megaloblastic anaemia; Methaemoglobinaemia; Erythema multiforme; Low blood sugar; Hepatitis (liver swelling); Crystalluria (crystals in the urine); Urinary obstruction causing difficulty passing urine
Trimethoprim (TMP) is an antibiotic used mainly in the treatment of bladder infections. [1] Other uses include for middle ear infections and travelers' diarrhea. [1] With sulfamethoxazole or dapsone it may be used for Pneumocystis pneumonia in people with HIV/AIDS. [1] [2] It is taken orally (swallowed by mouth). [1]
It is on the World Health Organization's List of Essential Medicines. [1] While benefits include being able to take less pills, it is unclear if this version changes peoples adherence to treatment. [2] Other studies, however, have found fixed-dose combinations to be useful for this purpose. [2]
If the abscess does not heal only with incision and drainage, or if the abscess is in a place that is difficult to drain such as the face, hands, or genitals, then antibiotics may be indicated. [ 1 ] In those cases of abscess which do require antibiotic treatment, Staphylococcus aureus bacteria is a common cause and an anti-staphylococcus ...
The diagnosis of M. abscessus pulmonary infection requires the presence of symptoms, radiologic abnormalities, and microbiologic cultures. [ citation needed ] M. abscessus can cause skin infections in immunodeficient patients, patients who have recently undergone surgery, tattooing , or acupuncture , or after exposure to hot springs or spas. [ 7 ]
There are a limited number of localized oral lesions that are indicated for antibiotic use and these include periodontal abscess, acute necrotizing ulcerative gingivitis, and pericoronitis. [1] A periapical abscess responds well to antibiotics if chewing gum is used during the first two half-lives of each dose (caution: overzealous mastication ...
Breakpoints for the same organism and antibiotic may differ based on the site of infection: [29] for example, the CLSI generally defines Streptococcus pneumoniae as sensitive to intravenous penicillin if MICs are ≤0.06 μg/ml, intermediate if MICs are 0.12 to 1 μg/ml, and resistant if MICs are ≥2 μg/ml, but for cases of meningitis, the ...
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