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Pfizer-BioNTech and Moderna vaccines are both mRNA vaccines with similar efficacy. Learn more about these as well as the Novavax vaccine.
Moderna COVID-19 vaccine 2024-2025 formula is authorized for people ages 6 months through 11 years. Spikevax is approved for people age 12 and older. The vaccines that help protect against COVID-19 are safe and effective based on clinical trials and continued monitoring.
First introduced in December 2020, the original COVID mRNA vaccines from both Pfizer and Moderna protected against the original SARS-CoV-2 virus. They have been replaced three times since then with shots targeting different iterations of the Omicron strain.
The study found that the Pfizer-BioNTech vaccine had an effectiveness of 88.8 percent, compared with Moderna’s 96.3 percent.
There is currently one FDA-approved COVID-19 vaccine — an mRNA vaccine (Pfizer’s Comirnaty). There are also two authorized COVID-19 vaccines available in the U.S. — one mRNA vaccine (Moderna) and one viral vector vaccine (Johnson & Johnson).
§ The mRNA COVID-19 vaccines (Moderna and Pfizer-BioNTech) are one type of COVID-19 vaccine and the protein subunit vaccine (Novavax) is another type of COVID-19 vaccine.
mRNA COVID-19 vaccines manufactured by Pfizer-BioNTech (BNT162b2) and Moderna (mRNA-1273) have been shown to be efficacious but have not been compared in head-to-head clinical trials.