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People have had severe infusion-related reactions to pembrolizumab. There have also been severe immune-related adverse effects including lung inflammation (including fatal cases) and inflammation of endocrine organs that caused inflammation of the pituitary gland, of the thyroid (causing both hypothyroidism and hyperthyroidism in different people), and pancreatitis that caused Type 1 diabetes ...
[20] [21] Later that year, Choueiri presented during the plenary session of the ASCO meeting the results of KEYNOTE-564 trial that showed for the first time that immunotherapy can be efficacious in the adjuvant setting in high-risk renal cancer, culminating in the FDA approval of pembrolizumab in RCC after surgery.
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When used as drugs, the International Nonproprietary Names (INNs) end in -mab. The remaining syllables of the INNs, as well as the column Source, are explained in Nomenclature of monoclonal antibodies. Types of monoclonal antibodies with other structures than naturally occurring antibodies.
Pembrolizumab: Merck: high risk, early-stage triple-negative breast cancer: Avalglucosidase alfa: Genzyme: late-onset Pompe disease: Lenvatinib: Eisai Inc: advanced renal cell carcinoma, used in combination with pembrolizumab: Difelikefalin: Cara Therapeutics: pruritis related to hemodialysis in chronic kidney disease: Mobocertinib: Takeda ...
Adjuvant therapy, also known as adjunct therapy, adjuvant care, or augmentation therapy, is a therapy that is given in addition to the primary or initial therapy to maximize its effectiveness. The surgeries and complex treatment regimens used in cancer therapy have led the term to be used mainly to describe adjuvant cancer treatments.
Overall, more than 30,000 employers across the US had at least one H-1B visa petition approved in 2024, and over half of those new petitions went to employers that filed 20 or fewer applications.
Renal cell carcinoma (RCC) is a kidney cancer that originates in the lining of the proximal convoluted tubule, a part of the very small tubes in the kidney that transport primary urine. RCC is the most common type of kidney cancer in adults, responsible for approximately 90–95% of cases. [1]
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