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SRX246, also known as API-246, is a small-molecule, centrally-active, highly-selective vasopressin V 1A receptor antagonist which is under investigation by Azevan Pharmaceuticals for the treatment of affective and anger disorders. [1] [2] [3] It is an azetidinone derivative, and was developed from LY-307174 as a lead compound. [4]
Intermittent explosive disorder (IED), or episodic dyscontrol syndrome (EDS), is a mental and behavioral disorder characterized by explosive outbursts of anger or violence, often to the point of rage, that are disproportionate to the situation at hand (e.g., impulsive shouting, screaming, or excessive reprimanding triggered by relatively inconsequential events).
Intermittent explosive disorder or IED is a clinical condition of experiencing recurrent aggressive episodes that are out of proportion of any given stressor. Earlier studies reported a prevalence rate between 1–2% in a clinical setting, however a study done by Coccaro and colleagues in 2004 had reported about 11.1% lifetime prevalence and 3. ...
This page was last edited on 3 September 2022, at 19:28 (UTC).; Text is available under the Creative Commons Attribution-ShareAlike 4.0 License; additional terms may apply.
A clinical research associate (CRA), also called a clinical monitor or trial monitor, is a health-care professional who performs many activities related to medical research, particularly clinical trials. Clinical research associates work in various settings, such as pharmaceutical companies, medical research institutes and government agencies.
Some of these disorders were formerly part of the chapter on early diagnosis, oppositional defiant disorder; conduct disorder; and disruptive behavior disorder not otherwise specified became other specified and unspecified disruptive disorder, impulse-control disorder, and conduct disorders. [11] Intermittent explosive disorder, pyromania, and ...
Here are links to possibly useful sources of information about Intermittent explosive disorder. PubMed provides review articles from the past five years (limit to free review articles) The TRIP database provides clinical publications about evidence-based medicine. Other potential sources include: Centre for Reviews and Dissemination and CDC
Three fundamental findings shaped HiTOP. [2] First, psychopathology is best characterized by dimensions rather than in discrete categories. [14] Dimensions are defined as continua that reflect individual differences in a maladaptive characteristic across the entire population (e.g., social anxiety is a dimension that ranges from comfortable social interactions to distress in nearly all social ...
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