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Norethisterone enanthate (NETE), also known as norethindrone enanthate, is a form of hormonal birth control which is used to prevent pregnancy in women. [ 1 ] [ 2 ] [ 3 ] It is used both as a form of progestogen-only injectable birth control and in combined injectable birth control formulations.
Norethisterone, as norethisterone acetate and norethisterone enanthate, has been studied for use as a potential male hormonal contraceptive in combination with testosterone in men. [ 124 ] [ 125 ] Long-acting norethisterone microspheres for intramuscular injection have been studied for potential use in birth control.
Norethisterone enanthate (brand names NET EN, Noristerat, Norigest, Doryxas) [5] – 200 mg (intramuscularly) every 2 months [3] Mechanism of action.
Norethisterone and ethinylestradiol levels over 24 hours after a single oral dose of 10 mg NETA in postmenopausal women. [ 25 ] NETA metabolizes into ethinylestradiol at a rate of 0.20 to 0.33% across a dose range of 10 to 40 mg. [ 26 ] [ 27 ] Peak levels of ethinylestradiol with a 10, 20, or 40 mg dose of NETA were 58, 178, and 231 pg/mL ...
In 2022, the combination of ethinylestradiol with norethisterone or with norethisterone acetate was the 80th most commonly prescribed medication in the United States, with more than 8 million prescriptions. [6] [7] It is available as a generic medication. [8]
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Formulations and brand names of norethisterone and esters Composition Dose Brand names Use NET only: Low (e.g., 0.35 mg) Multiple [a] Progestogen-only oral contraceptive: NET or NETA only: High (e.g., 5 mg, 10 mg) Multiple [b] Gynecological disorders and other uses NETE only: Injection (e.g., 200 mg) Multiple [c] Progestogen-only injectable ...