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Unresectable liver cancer of primary or secondary origin, such as hepatocellular carcinoma [4] and liver-metastases from a different origin (e.g. colorectal cancer, [5] breast cancer, [6] neuroendocrine cancer, [7] cholangiocarcinoma [8] or soft tissue sarcomas [9]) No response or intolerance to regional or systemic chemotherapy
A liver metastasis is a malignant tumor in the liver that has spread from another organ that is affected by cancer. The liver is a common site for metastatic disease because of its rich, dual blood supply (the liver receives blood via the hepatic artery and portal vein). Metastatic tumors in the liver are 20 times more common than primary liver ...
Staging breast cancer is the initial step to help physicians determine the most appropriate course of treatment. As of 2016, guidelines incorporated biologic factors, such as tumor grade, cellular proliferation rate, estrogen and progesterone receptor expression, human epidermal growth factor 2 (HER2) expression, and gene expression profiling into the staging system.
This is an accepted version of this page This is the latest accepted revision, reviewed on 3 March 2025. Cancer that originates in mammary glands Medical condition Breast cancer An illustration of breast cancer Specialty Surgical oncology Symptoms A lump in a breast, a change in breast shape, dimpling of the skin, fluid from the nipple, a newly inverted nipple, a red scaly patch of skin on the ...
Metastatic lesions from breast cancer may produce symptoms according to that organ system. The most common sites for metastasis are the bone, lung, liver, and brain. [17] Skin metastases most commonly extend to the skin overlying the mass, but may spread to the axilla or more distant areas. [18]
The esophagus can also become sore if it is treated directly, or if, as commonly occurs, it receives a dose of collateral radiation during treatment of lung cancer. When treating liver malignancies and metastases, it is possible for collateral radiation to cause gastric, stomach, or duodenal ulcers [21] [22] This collateral radiation is ...
1990s – RFA for soft tissue tumors, i.e., bone, breast, kidney, lung and liver cancer. 1997 – Intra-arterial delivery of tumor-killing viruses and gene therapy vectors to the liver. 1997 – HIFU first used to treat prostate cancer. 2012 – Pioneering liver chemoperfusion study reported by Delcath for disseminated liver metastases. [32]
Metastatic breast cancer to the lung or pleura causes chronic cough, dyspnea, abnormal chest X-ray, and chest pain. Other nonspecific systemic symptoms of metastatic breast cancer include fatigue, malaise, weight loss, and poor appetite. Sometimes people with metastatic breast cancer do not have any notable changes or symptoms. [8]
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