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Unresectable liver cancer of primary or secondary origin, such as hepatocellular carcinoma [4] and liver-metastases from a different origin (e.g. colorectal cancer, [5] breast cancer, [6] neuroendocrine cancer, [7] cholangiocarcinoma [8] or soft tissue sarcomas [9]) No response or intolerance to regional or systemic chemotherapy
Common sites of metastasis for breast cancer. Metastatic breast cancer, also referred to as metastases, advanced breast cancer, secondary tumors, secondaries or stage IV breast cancer, is a stage of breast cancer where the breast cancer cells have spread to distant sites beyond the axillary lymph nodes. There is no cure for metastatic breast ...
A liver metastasis is a malignant tumor in the liver that has spread from another organ that is affected by cancer. The liver is a common site for metastatic disease because of its rich, dual blood supply (the liver receives blood via the hepatic artery and portal vein). Metastatic tumors in the liver are 20 times more common than primary liver ...
Key to successful treatment is early diagnosis, before the cancer has a chance to metastasize, or spread, from its original location. More than 90% of cancer deaths happen after cancer has spread ...
This is an accepted version of this page This is the latest accepted revision, reviewed on 3 March 2025. Cancer that originates in mammary glands Medical condition Breast cancer An illustration of breast cancer Specialty Surgical oncology Symptoms A lump in a breast, a change in breast shape, dimpling of the skin, fluid from the nipple, a newly inverted nipple, a red scaly patch of skin on the ...
According to Penn Medicine, metastatic breast cancer is a late-stage form of the disease that occurs when cancerous cells have migrated from the breast to other parts of the body—most commonly ...
Staging breast cancer is the initial step to help physicians determine the most appropriate course of treatment. As of 2016, guidelines incorporated biologic factors, such as tumor grade, cellular proliferation rate, estrogen and progesterone receptor expression, human epidermal growth factor 2 (HER2) expression, and gene expression profiling into the staging system.
Metastatic lesions from breast cancer may produce symptoms according to that organ system. The most common sites for metastasis are the bone, lung, liver, and brain. [17] Skin metastases most commonly extend to the skin overlying the mass, but may spread to the axilla or more distant areas. [18]