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Cyproheptadine, sold under the brand name Periactin among others, is a first-generation antihistamine with additional anticholinergic, antiserotonergic, and local anesthetic properties. It was patented in 1959 and came into medical use in 1961. [ 5 ]
Second-generation H 1-antihistamines are newer drugs that are much more selective for peripheral H 1 receptors as opposed to the central nervous system H 1 receptors and cholinergic receptors. This selectivity significantly reduces the occurrence of adverse drug reactions, such as sedation, while still providing effective relief of allergic ...
The use of sedating drugs alongside hydroxyzine can cause oversedation and confusion if administered at high doses—any form of hydroxyzine treatment alongside sedatives should be done under the supervision of a doctor. [28] [25] Because of the potential for more severe side effects, this drug is on the list to avoid in the elderly. [29]
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Cyproheptadine, a non-selective serotonin receptor antagonist (including of the serotonin 5-HT 2A receptor), is used as an antidote in the treatment of serotonin syndrome (or serotonin toxicity) caused by serotonergic drugs, including the toxicity of serotonergic psychedelics like the NBOMe drugs.
Ibuprofen (Advil) or other anti-inflammatory drugs. Local anesthetics or other medications that can reduce your pain levels. Antidepressants: Though it sounds strange, Medical News Today reports ...