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Drug content uniformity is a requirement for all dosage forms, particularly those containing low dose highly potent drugs. To uniquely meet this requirement, thin film formulations contain uniform dispersions of drug throughout the whole manufacturing process. [ 5 ]
In addition, the Joint Formulary Committee takes advice on all therapeutic areas from advisers from expert groups; this ensures that the BNF's recommendations are relevant to practice. In September 2016, the National Institute for Health and Care Excellence (NICE) in the UK gave NICE accreditation to the processes to produce BNF publications; a ...
Footnotes: a = No longer used or recommended, due to health concerns. b = As a single patch applied once or twice per week (worn for 3–4 days or 7 days), depending on the formulation. Note: Dosages are not necessarily equivalent.
The therapeutic index (TI; also referred to as therapeutic ratio) is a quantitative measurement of the relative safety of a drug with regard to risk of overdose.It is a comparison of the amount of a therapeutic agent that causes toxicity to the amount that causes the therapeutic effect. [1]
It has been found to suppress testosterone levels by 57% at a dosage of 100 mg/week and by 70% at a dosage of 300 mg/week in men following 6 weeks of treatment. [3] Both the androgenic activity and the progestogenic activity of nandrolone decanoate may contribute to its antigonadotropic potency. [3]
Physical activity in children may not be a significant contributor. [132] In both children and adults, there is an association between television viewing time and the risk of obesity. [133] [134] [135] Increased media exposure increases the rate of childhood obesity, with rates increasing proportionally to time spent watching television. [136]
For the European Union, the EFSA set higher recommendations for adults, and also for children: 20 mg/day for ages 1–3, 30 mg/day for ages 4–6, 45 mg/day for ages 7–10, 70 mg/day for ages 11–14, 100 mg/day for males ages 15–17, 90 mg/day for females ages 15–17. For pregnancy 100 mg/day; for lactation 155 mg/day. [20]
As of 2005, the only childhood vaccine in the U.S. that contains thiomersal in greater than trace amounts is the influenza vaccine, [90] which is currently recommended only for children with certain risk factors. [91] Single-dose influenza vaccines supplied in the UK do not list thiomersal in the ingredients.