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Metformin is a pleiotropic drug, with extensive off-target activity beyond its antidiabetic effect. Much of this has been attributed to its action on AMPK, although other mechanisms have been proposed. [215] [216] Metformin has been studied for its effects on multiple other conditions, including: Non-alcoholic fatty liver disease [217] [218] [219]
Gabapentin, sold under the brand name Neurontin among others, is an anticonvulsant medication primarily used to treat partial seizures and neuropathic pain. [7][10] It is a commonly used medication for the treatment of neuropathic pain caused by diabetic neuropathy, postherpetic neuralgia, and central pain. [11]
Anticonvulsant. Anticonvulsants (also known as antiepileptic drugs, antiseizure drugs, or anti-seizure medications (ASM)) are a diverse group of pharmacological agents used in the treatment of epileptic seizures. [1] Anticonvulsants are also increasingly being used in the treatment of bipolar disorder [2][3] and borderline personality disorder ...
The oral bioavailability of gabapentin enacarbil (as gabapentin) is greater than or equal to 68%, across all doses assessed (up to 2,800 mg), with a mean of approximately 75%. [ 24 ] [ 1 ] In contrast to the other gabapentinoids, the pharmacokinetics of phenibut have been little-studied, and its oral bioavailability is unknown. [ 15 ]
Side effects of metformin are typically mild and include GI (gastrointestinal) issues like gas, diarrhea or bloating. However, the FDA warns against using metformin if you have kidney disease or a ...
It is taken by mouth. [13] Common side effects include headache, dizziness, sleepiness, confusion, trouble with memory, poor coordination, dry mouth, problems with vision, and weight gain. [13][29] Serious side effects may include angioedema, drug misuse, and an increased suicide risk. [13]
It contains empagliflozin and metformin hydrochloride. [4] [5] It is taken by mouth. [4] [5] The most common side effects include hypoglycaemia (low blood sugar levels) when the medicine is taken with a sulphonylurea or insulin, infections of the urinary tract and genitals, and increased urination. [5]
Serious side effects may include lactic acidosis, pancreatitis, low blood sugar, heart failure, joint pain, and allergic reactions. [5] It has not been properly studied in women who are pregnant or breastfeeding. [1] It contains sitagliptin (a dipeptidyl peptidase-4 inhibitor) and metformin (a biguanide). [5]
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