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A classic example of a syncytium is the formation of skeletal muscle.Large skeletal muscle fibers form by the fusion of thousands of individual muscle cells. The multinucleated arrangement is important in pathologic states such as myopathy, where focal necrosis (death) of a portion of a skeletal muscle fiber does not result in necrosis of the adjacent sections of that same skeletal muscle ...
Skeletal muscle cells form by fusion of myoblasts to produce multinucleated cells in a process known as myogenesis. [4] [5] Skeletal muscle cells and cardiac muscle cells both contain myofibrils and sarcomeres and form a striated muscle tissue. [6]
Multinucleate cells (also known as multinucleated cells or polynuclear cells) are eukaryotic cells that have more than one nucleus, i.e., multiple nuclei share one common cytoplasm. Mitosis in multinucleate cells can occur either in a coordinated, synchronous manner where all nuclei divide simultaneously or asynchronously where individual ...
Skeletal muscle cells are the individual contractile cells within a muscle, and are often termed as muscle fibers. [3] A single muscle such as the biceps in a young adult male contains around 253,000 muscle fibers. [22] Skeletal muscle fibers are multinucleated with the nuclei often referred to as myonuclei.
Myoblasts (cells with a single nucleus, represented in violet) fusing together to form muscle fibers (multinucleated muscle cells) during myogenesis. Myogenesis is the formation of skeletal muscular tissue, particularly during embryonic development.
Skeletal muscle tissue is striated consisting of elongated, multinucleate muscle cells called muscle fibers, and is responsible for movements of the body. Other tissues in skeletal muscle include tendons and perimysium. [3] Smooth and cardiac muscle contract involuntarily, without conscious intervention.
A smooth-muscle cell is a spindle-shaped myocyte with a wide middle and tapering ends, and a single nucleus. Like striated muscle, smooth muscle can tense and relax. In the relaxed state, each cell is 30–200 micrometers in length, some thousands of times shorter than a skeletal muscle cell. [1]
Cell fusion is an important cellular process in which several uninucleate cells (cells with a single nucleus) combine to form a multinucleate cell, known as a syncytium. Cell fusion occurs during differentiation of myoblasts , osteoclasts and trophoblasts , during embryogenesis , and morphogenesis . [ 1 ]