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By blocking DHT production directly at the source, finasteride drastically reduces the levels of DHT in your body. Research shows that it can lower the amount of DHT by as much as 70 percent.
DHT is a potent agonist of the AR, and is in fact the most potent known endogenous ligand of the receptor. It has an affinity (K d) of 0.25 to 0.5 nM for the human AR, which is about 2- to 3-fold higher than that of testosterone (K d = 0.4 to 1.0 nM) [47] and 15–30 times higher than that of adrenal androgens. [48]
Finasteride (brand names Proscar, Propecia) inhibits the function of two of the isoenzymes (types 2 and 3) of 5α-reductase. [6][7] It decreases circulating DHT levels by up to about 70%. [8] Dutasteride (brand name Avodart) inhibits all three 5α-reductase isoenzymes and can decrease DHT levels by 95%. [9][10] It can also reduce DHT levels in ...
Schematic diagram of the canonical (left), backdoor (middle), and 11-oxy backdoor (right) pathways of androgen biosynthesis. The androgen backdoor pathway is responsible for the synthesis of physiologically relevant androgens. This process starts with 21-carbon (C21) steroids, also known as pregnanes, and involves a step called "5α- reduction ".
Countless vitamins and minerals, including vitamins A, B7, B12 and essential nutrients such as zinc and iron, all play key roles in your body’s process for growing and maintaining your hair. Try ...
Dr. Gohara's a fan of Nutrafol because it's chock-full of antioxidants, including resveratrol, collagen (the primary building block of hair), curcumin, vitamin E, and kelp. "This combo of ...
5α-Reductase 2 deficiency (5αR2D) is an autosomal recessive condition caused by a mutation in SRD5A2, a gene encoding the enzyme 5α-reductase type 2 (5αR2). The condition is rare, affects only genetic males, and has a broad spectrum. 5αR2 is expressed in specific tissues and catalyzes the transformation of testosterone (T) to 5α ...
Dihydrotestosterone (DHT), a metabolite of testosterone, is a critical mediator of prostatic growth. DHT is synthesized in the prostate from circulating testosterone by the action of the enzyme 5α-reductase, type 2. DHT can act in an autocrine fashion on the stromal cells or in paracrine fashion by diffusing into nearby epithelial cells.
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