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Stress suppresses TSH, [5] and alterations in thyroid hormone levels may arise in psychiatric illness. In major depressive disorder, an NTIS-like phenotype may be observed, with reduced T3 and increased rT3. T4 may be elevated, and TSH is usually normal, although TSH's normal circadian rhythm may be disrupted. [2]
Childhood trauma can severely affect the development of the brain, resulting in the alteration of neural circuits which are involved in emotional regulation and threat detection. Childhood trauma has been associated with a wide array of mental health disorders such as bipolar disorder, anxiety, post traumatic stress disorder (PTSD), and depression.
Some studies contradict the psychological findings. For example, a large 2002 study found "no statistical association between thyroid dysfunction, and the presence of depression or anxiety disorder." [31] In one study on hospitalised elderly patients, over half had cognitive impairment with either dementia or confusion. [32]
Trauma survivors often develop depression, anxiety disorders, and mood disorders in addition to PTSD. [36] More than 50% of those with PTSD have co-morbid anxiety, mood, or substance use disorders. [37] Substance use disorder, such as alcohol use disorder, commonly co-occur with PTSD. [38]
More generally, negative or stressful life events have been implicated in the development of a range of disorders, including mood and anxiety disorders. [75] [76] The main risks appear to be from the accumulation of such experiences over time, although a single major trauma can sometimes lead to disorders, especially post-traumatic stress disorder.
In adolescents, emotional dysregulation is a risk factor for many mental health disorders including depressive disorders, anxiety disorders, post-traumatic stress disorder, bipolar disorder, borderline personality disorder, substance use disorder, alcohol use disorder, eating disorders, oppositional defiant disorder, and disruptive mood ...
Post traumatic stress disorder: Post-traumatic stress disorder is a disorder which is associated with frequently being disturbed by flashback memories and being haunted by feelings of fear and horror in the past. This contributes to the alteration of mood that occurs after a traumatic event happens, such as depression, outbursts of anger, self ...
Depression may be related to abnormalities in the circadian rhythm, [22] or biological clock. A well synchronized circadian rhythm is critical for maintaining optimal health. Adverse changes and alterations in the circadian rhythm have been associated with various neurological disorders and mood disorders including depression. [23]
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