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Skeletochronology is a technique used to determine the individual, chronological ages of vertebrates by counting lines of arrested, annual growth, also known as LAGs, within skeletal tissues. [1] Within the annual bone growth specimens, there are broad and narrow lines. Broad lines represent the growth period and narrow lines represent a growth ...
Wolff's law, developed by the German anatomist and surgeon Julius Wolff (1836–1902) in the 19th century, states that bone in a healthy animal will adapt to the loads under which it is placed. [1] If loading on a particular bone increases, the bone will remodel itself over time to become stronger to resist that sort of loading.
It’s composed of highly active chondrocytes and responsible for longitudinal bone growth. Consequently, the bone elongates at this growth plate until closure occurs at skeletal maturity. At the end of an individual’s growth period, the production of new cartilage in the epiphyseal plate stops.
The first step in the process is the formation of bone spicules which eventually fuse with each other and become trabeculae. The periosteum is formed and bone growth continues at the surface of trabeculae. Much like spicules, the increasing growth of trabeculae result in interconnection and this network is called woven bone.
The epiphyseal plate, epiphysial plate, physis, or growth plate is a hyaline cartilage plate in the metaphysis at each end of a long bone.It is the part of a long bone where new bone growth takes place; that is, the whole bone is alive, with maintenance remodeling throughout its existing bone tissue, but the growth plate is the place where the long bone grows longer (adds length).
Growth arrest lines, also known as Harris lines, are lines of increased bone density that represent the position of the growth plate at the time of insult to the organism and formed on long bones due to growth arrest. They are only visible by radiograph or in cross-section. The age at which the lines were formed can be estimated from a radiograph.
A bone growth factor is a growth factor that stimulates the growth of bone tissue. [1] [2]Known bone growth factors include insulin-like growth factor-1 (IGF-1), insulin-like growth factor-2 (IGF-2), transforming growth factor beta (TGF-β), fibroblast growth factors (FGFs), platelet-derived growth factor (PDGF), parathyroid hormone-related peptide (PTHrP), bone morphogenetic proteins (BMPs ...
A spotted gar larva at 22 days stained for cartilage (blue) and bone (red). Chondrogenesis is the biological process through which cartilage tissue is formed and developed. . This intricate and tightly regulated cellular differentiation pathway plays a crucial role in skeletal development, as cartilage serves as a fundamental component of the embryonic skele