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Phenylbiguanide (PBG) is a 5-HT3 agonist used to study the role of 5-HT3 receptors in the central nervous system. [1] It has been found to trigger dopamine release in the nucleus accumbens of rats. [ 2 ]
Galega officinalis (French lilac) was used in diabetes treatment for centuries. [5] In the 1920s, guanidine compounds were discovered in Galega extracts. Animal studies showed that these compounds lowered blood glucose levels.
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BMB-201 is a serotonin 5-HT 2A and 5-HT 2C receptor agonist described as a non-hallucinogenic psychoplastogen which is under development for the treatment of depression, anxiety, pain, and other indications.
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BFAI (5,6-benzofuranyl-2-aminoindane) is a drug of the 2-aminoindane group that acts as a serotonin releasing agent (SSRA) and produces entactogen effects in humans, which may be useful for psychotherapeutic applications.