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The cells in the respiratory epithelium are of five main types: a) ciliated cells, b) goblet cells, c) brush cells, d) airway basal cells, and e) small granule cells (NDES) [6] Goblet cells become increasingly fewer further down the respiratory tree until they are absent in the terminal bronchioles; club cells take over their role to some extent here. [7]
Type I cells are the larger of the two cell types; they are thin, flat epithelial lining cells (membranous pneumocytes), that form the structure of the alveoli. [3] They are squamous (giving more surface area to each cell) and have long cytoplasmic extensions that cover more than 95% of the alveolar surface.
About 20,000 protein coding genes are expressed in human cells and almost 75% of these genes are expressed in the normal lung. [ 83 ] [ 84 ] A little less than 200 of these genes are more specifically expressed in the lung with less than 20 genes being highly lung specific.
Micrograph showing hemosiderin-laden alveolar macrophages, as seen in a pulmonary hemorrhage. H&E stain.. An alveolar macrophage, pulmonary macrophage, (or dust cell) is a type of macrophage, a professional phagocyte, found in the airways and at the level of the alveoli in the lungs, but separated from their walls.
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The normal ratio of ciliated cells to secretory cells is 10 to 1, and this is highly controlled throughout most of the respiratory tree. [3] When this ratio is upset in this way, the effect is of generating the mucus hyperplasia associated with a number of respiratory diseases, due to the insufficient ciliary action needed for mucociliary ...
Diagrammatic view of exaggerated pleural space. Cytology of the normal mesothelial cells that line the pleurae, with typical features. [3] Wright's stain.. Each pleura comprises a superficial serosa made of a simple monolayer of flat (squamous) or cuboidal mesothelial cells with microvilli up to 6 μm (0.00024 in) long.
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