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In epidemiology, a clinical case definition, [1] a clinical definition, or simply a case definition [2] lists the clinical criteria by which public health professionals determine whether a person's illness is included as a case in an outbreak investigation—that is, whether a person is considered directly affected by an outbreak.
Both the relative risk and odds ratio are relevant in retrospective cohort studies, but only the odds ratio can be used in case-control studies. Although most case-control studies are retrospective, they can also be prospective when the researcher still enrolls participants based on the occurrence of a disease as new cases occur. [citation needed]
Case series have a descriptive study design; unlike studies that employ an analytic design (e.g. cohort studies, case-control studies or randomized controlled trials), case series do not, in themselves, involve hypothesis testing to look for evidence of cause and effect (though case-only analyses are sometimes performed in genetic epidemiology ...
An example of an epidemiological question that can be answered using a cohort study is whether exposure to X (say, smoking) associates with outcome Y (say, lung cancer). For example, in 1951, the British Doctors Study was started. Using a cohort which included both smokers (the exposed group) and non-smokers (the unexposed group).
The index case or patient zero is the first documented patient in a disease epidemic within a population, [1] or the first documented patient included in an epidemiological study. [2] It can also refer to the first case of a condition or syndrome (not necessarily contagious) to be described in the medical literature, whether or not the patient ...
For example, prevention and control measures are usually implemented very early in the investigation, often before the causative agent is known. In many situations, promoting good hygiene and hand-washing is one of the first things recommended. Other interventions may be added as the investigation moves forward and more information is obtained.
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Some case reports also contain a literature review of other reported cases. Case reports are professional narratives that provide feedback on clinical practice guidelines and offer a framework for early signals of effectiveness, adverse events, and cost. They can be shared for medical, scientific, or educational purposes.