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Of them, 1,3,4-thiadiazole is the most common, appearing in such medications as cephazolin and acetazolamide. [ 1 ] [ 2 ] [ 3 ] In the Hurd-Mori reaction , an acyl hydrazone reacts with thionyl chloride or selenium dioxide to give a 1‑thia- or 1‑selena-2,3‑diazole.
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2,1,3-Benzothiadiazole has been of interest as a redox-active organic component in flow batteries owing to its favourable solubility, low reduction potential and fast electrochemical kinetics. [ 15 ] Such properties in derivatives containing this heterocycle have made it of growing interest in dyestuffs , [ 16 ] white light-emitting polymers ...
1,2,3-benzothiadiazole is much less nucleophilic than naphthalene. Nitration is slow. [8] For that reason, many of its simple derivatives have been made from 2-aminothiophenols already having additional substituents. [7] 1,2,3-benzothiadiazole is a very weak base and alkylation reactions give exclusively the 3-amino quaternary salt. [9]
The Hurd–Mori 1,2,3-thiadiazole synthesis is a name reaction in organic chemistry that allows for the generation of 1,2,3-thiadiazoles through the reaction of hydrazone derivatives with an N-acyl or N-tosyl group reacted with thionyl chloride.
Skeletal formula of fluconazole - an antifungal medication. The search for antifungal agents with acceptable toxicity profiles led first to the discovery of ketoconazole, the first azole-based oral treatment of systemic fungal infections, in the early 1980s.
Archive (Vol 1–27) Bioscience, Biotechnology, and Biochemistry is a monthly, peer-reviewed , scientific journal published by the Japan Society for Bioscience, Biotechnology and Agrochemistry , of which it is the official journal.
This intermediate, as its hydrochloride salt, is treated with sodium nitrite in water to give 7-methoxycarbonyl-1,2,3-benzothiadiazole in 86% yield after recrystallization. Conversion of the ester into the thioester is by hydrolysis to form the free carboxylic acid followed by its conversion to the S -methyl thioester in a standard chemical ...