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Prednisolone can also be used for allergic reactions ranging from seasonal allergies to drug allergic reactions. [25] Prednisolone can also be used as an immunosuppressant for organ transplants. [7] [26] Prednisolone in lower doses can be used in cases of adrenal insufficiency due to Addison's disease. [27] [28]
Emergent intramuscular dosing can be given if child is not tolerating oral medications or unable to get IV within 15 minutes. IM hydrocortisone sodium succinate doses are: [3] 25 mg for child 3 years and younger; 50 mg for children >3 yrs – 12 years; 100 mg for children 12 years and older.
The procedure is to take the child's weight in pounds, divide by 150 lb, and multiply the fractional result by the adult dose to find the equivalent child dosage.For example, if an adult dose of medication calls for 30 mg and the child weighs 30 lb, divide the weight by 150 (30/150) to obtain 1/5 and multiply 1/5 times 30 mg to get 6 mg.
Then change to oral hydrocortisone or cortisone as a single morning dose, and gradually decrease by 2.5 mg each week. When the morning dose is less than replacement, the return of normal basal adrenal function may be documented by checking 0800 cortisol levels prior to the morning dose; stop drugs when 0800 cortisol is 10 μg/dl.
It contains a wide range of information and advice on prescribing for children - from newborn to adolescence. The entries are classified by group of drug, giving cautions for use, side effects, indications and dose for most of the drugs available for children in the UK National Health Service. It also includes information on the unlicensed uses ...
Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex of vertebrates, as well as the synthetic analogues of these hormones.Two main classes of corticosteroids, glucocorticoids and mineralocorticoids, are involved in a wide range of physiological processes, including stress response, immune response, and regulation of inflammation, carbohydrate metabolism ...
Chol [1] 5-cholesten-3beta-ol Progestogens; Pregnenolone: P5 [2] or Preg [3] 3beta-hydroxy-5-pregnen-20-one 17α-Hydroxypregnenolone: 17-OHP5 [4] or 17P5 [5] 3beta,17-dihydroxy-5-pregnen-20-one Progesterone: P4 [6] or P [3] 4-pregnene-3,20-dione 17α-Hydroxyprogesterone: 17-OHP4 [4] or 17OHP [7] or 17P4 [5] 17α-hydroxy-4-pregnene-3,20-dione ...
[4] [3] It is generally considered safe in pregnancy and low doses appear to be safe while the user is breastfeeding. [5] After prolonged use, prednisone must be stopped gradually. [3] Prednisone is a prodrug and must be converted to prednisolone by the liver before it becomes active.
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