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A contrast agent (or contrast medium) is a substance used to increase the contrast of structures or fluids within the body in medical imaging. [1] Contrast agents absorb or alter external electromagnetism or ultrasound , which is different from radiopharmaceuticals , which emit radiation themselves.
Contrast-enhanced ultrasound (CEUS) is the application of ultrasound contrast medium to traditional medical sonography. Ultrasound contrast agents rely on the different ways in which sound waves are reflected from interfaces between substances. This may be the surface of a small air bubble or a more complex structure.
They are used in medical diagnostics as a contrast agent for ultrasound imaging. [4] The gas-filled microbubbles, typically air or perfluorocarbon, oscillate, and vibrate if a sonic energy field is applied and may reflect ultrasound waves. This distinguishes the microbubbles from surrounding tissues.
A contrast medium for medical ultrasonography is a formulation of encapsulated gaseous microbubbles [64] to increase echogenicity of blood, discovered by Dr. Raymond Gramiak in 1968 [65] and named contrast-enhanced ultrasound. This contrast medical imaging modality is used throughout the world, [66] for echocardiography in particular in the ...
The most common example of molecular imaging used clinically today is to inject a contrast agent (e.g., a microbubble, metal ion, or radioactive isotope) into a patient's bloodstream and to use an imaging modality (e.g., ultrasound, MRI, CT, PET) to track its movement in the body.
Contrast agents with therapeutic properties have been under development for several years. [8] One example is the design of contrast agents capable of releasing a chemotherapeutic agent locally at the target site, triggered by a stimulus provided by the operator. This localized approach aims to increase treatment efficacy and minimize side effects.
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