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Aziridine is an organic compound consisting of the three-membered heterocycle C 2 H 5 N. [ 5 ] [ 6 ] It is a colorless, toxic, volatile liquid that is of significant practical interest. [ 7 ] Aziridine was discovered in 1888 by the chemist Siegmund Gabriel . [ 8 ]
Mitomycin C, an aziridine, is used as a chemotherapeutic agent by virtue of its antitumour activity. [1]In organic chemistry, aziridines are organic compounds containing the aziridine functional group (chemical structure (R−) 4 C 2 N−R), a three-membered heterocycle with one amine (>NR) and two methylene bridges (>CR 2).
Aziridine; Ethanimine or its tautomer, vinylamine; N-Methylmethanimine This page was last edited on 27 December 2022, at 20:58 (UTC). Text is available under ...
This reaction has three points of chemical diversity as the structure of the aziridine starting compound, the organometallic reagent, and the electrophile can all be varied to synthesize a different hydantoin. [6]
Azirines are three-membered heterocyclic unsaturated (i.e. they contain a double bond) compounds containing a nitrogen atom and related to the saturated analogue aziridine. [1] They are highly reactive yet have been reported in a few natural products such as Dysidazirine.
Aziridiniums are the ionic form of the class of molecules known as aziridines. [1] Aziridines can be used to insert nitrogen atoms during synthesis, but without any substituents attached to the nitrogen in the ring, they are considered nonactivated and inert. [2] They can be rendered active by the preparation of aziridinium ions.
Chemical structure of mitomycin C. The mitomycins are a family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae. [1] [2] They include mitomycin A, mitomycin B, and mitomycin C. When the name mitomycin occurs alone, it usually refers to mitomycin C, its international nonproprietary name ...
The Blum–Ittah aziridine synthesis, also known as the Blum–Ittah-Shahak aziridine synthesis [1] or simply the Blum aziridine synthesis is a name reaction of organic chemistry, for the generation of aziridines from oxiranes.