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Aziridine is an organic compound consisting of the three-membered heterocycle C 2 H 5 N. [ 5 ] [ 6 ] It is a colorless, toxic, volatile liquid that is of significant practical interest. [ 7 ] Aziridine was discovered in 1888 by the chemist Siegmund Gabriel . [ 8 ]
Mitomycin C, an aziridine, is used as a chemotherapeutic agent by virtue of its antitumour activity. [1]In organic chemistry, aziridines are organic compounds containing the aziridine functional group (chemical structure (R−) 4 C 2 N−R), a three-membered heterocycle with one amine (>NR) and two methylene bridges (>CR 2).
Polyethylenimine (PEI) or polyaziridine is a polymer with repeating units composed of the amine group and two carbon aliphatic CH 2 CH 2 spacers. Linear polyethyleneimines contain all secondary amines, in contrast to branched PEIs which contain primary, secondary and tertiary amino groups.
This chemical is used in the paper, textile, rubber and pharmaceutical industries. Propyleneimine is also used in making paint. The top global producers of this specialty chemical include DuPont, Mitsubishi Chemical Holdings Corporation, Sigma-Aldrich, Dixie Chemical Company, J and K Scientific, Apollo Scientific, Mitsui Chemicals.
The Blum–Ittah aziridine synthesis, also known as the Blum–Ittah-Shahak aziridine synthesis [1] or simply the Blum aziridine synthesis is a name reaction of organic chemistry, for the generation of aziridines from oxiranes.
The Wenker synthesis is an organic reaction converting a beta amino alcohol to an aziridine with the help of sulfuric acid. It is used industrially for the synthesis of aziridine itself. [1] Wenker synthesis. The original Wenker synthesis of aziridine itself takes place in two steps.
The De Kimpe aziridine synthesis is a name reaction of organic chemistry, for the generation of aziridines by the reaction of α-chloroimines with nucleophiles such as hydride, [1] cyanide, or Grignard reagents. [2] [3]
The mitomycins are a family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae. [1] [2] They include mitomycin A, mitomycin B, and mitomycin C. When the name mitomycin occurs alone, it usually refers to mitomycin C, its international nonproprietary name. Mitomycin C is used as a medicine ...