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Clavulanic acid is a β-lactam drug that functions as a mechanism-based β-lactamase inhibitor.While not effective by itself as an antibiotic, when combined with penicillin-group antibiotics, it can overcome antibiotic resistance in bacteria that secrete β-lactamase, which otherwise inactivates most penicillins.
The dose-limiting side effects are liver damage, lung disease and immunosuppression. [27] The most common side effects (occurring in >1% of those treated with it) are, in approximately descending order of frequency: [7] [10] [2] [28] [29] [5] [4] diarrhea, respiratory tract infections, hair loss, high blood pressure, rash, nausea, bronchitis, headache, abdominal pain, abnormal liver function ...
Research on the medicinal effects of gold began in 1935, [2] primarily to reduce inflammation and to slow disease progression in patients with rheumatoid arthritis. The use of gold compounds has decreased since the 1980s because of numerous side effects and monitoring requirements, limited efficacy, and very slow onset of action.
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A 2005 Cochrane review states that low level laser therapy can be tried to improve pain and morning stiffness due to rheumatoid arthritis as there are few side-effects. [ 166 ] There is limited evidence that tai chi might improve the range of motion of a joint in persons with rheumatoid arthritis.
[3] [104] This is due to their small benefit and relatively large risk of side effects. [105] [106] The use of tramadol likely does not improve pain or physical function and likely increases the incidence of adverse side effects. [106] Oral steroids are not recommended in the treatment of osteoarthritis. [95]
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