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Top: An ancestral gene duplication produces two paralogs (histone H1.1 and 1.2). A speciation event produces orthologs in the two daughter species (human and chimpanzee). Bottom: in a separate species , a gene has a similar function (histone-like nucleoid-structuring protein) but has a separate evolutionary origin and so is an analog.
Cyclin-dependent kinase 1 also known as CDK1 or cell division cycle protein 2 homolog is a highly conserved protein that functions as a serine/threonine protein kinase, and is a key player in cell cycle regulation. [5]
English: Levels of the three major cyclin types oscillate during the cell cycle (top), providing the basis for oscillations in the cyclin–Cdk complexes that drive cell-cycle events (bottom). In general, Cdk levels are constant and in large excess over cyclin levels; thus, cyclin–Cdk complexes form in parallel with cyclin levels.
Alignments of multiple sequences are used to indicate which regions of each sequence are homologous. [ 40 ] Homologous sequences are orthologous if they are descended from the same ancestral sequence separated by a speciation event: when a species diverges into two separate species, the copies of a single gene in the two resulting species are ...
5883 19367 Ensembl ENSG00000172613 ENSMUSG00000024824 UniProt Q99638 Q9Z0F6 RefSeq (mRNA) NM_001243224 NM_004584 NM_011237 RefSeq (protein) NP_001230153 NP_004575 NP_035367 Location (UCSC) Chr 11: 67.32 – 67.4 Mb Chr 19: 4.25 – 4.25 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Cell cycle checkpoint control protein RAD9A is a protein that in humans is encoded by the RAD9A gene ...
Homologies are usually determined on the basis of high bit score BLAST hits that occur between multiple genomes. From here, dynamic programming is used to select the best scoring path of shared homologous genes between species, taking into account potential gene loss and gain which may have occurred in the species' evolutionary histories.
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However, recent studies using fluorescent labeled Rad51 [11] have indicated that Rad51 fragments elongate via multiple nucleation events followed by growth, with the total fragment terminating when it reaches about 2 μm in length. However, disassociation of Rad51 from dsDNA is slow and incomplete, suggesting that there is a separate mechanism ...